San Francisco 49ers @ Seattle Seahawks
Seattle Seahawks projected to win thanks to stronger defensive efficiency over San Francisco 49ers. Model assigns a 53% confidence to this outcome.
Win Probability
Team Profile
SF
SEAKey Factors
Game Projections
Derived from each team's last 6-game scoring averages vs opponent defense
SF
21.1
proj pts
Total O/U
46.5
pts
SEA
25.4
proj pts
Scoring Edges
Seattle Seahawks Offense
21.5 PPG vs San Francisco 49ers (allows 29.3)
San Francisco 49ers Offense
21.5 PPG vs Seattle Seahawks (allows 20.7)
Projections use rolling 6-game team averages. Not financial advice.
Analytics Breakdown
Model-derived betting metrics & edge factors
Proj Spread
Seahawks -6
Total O/U
45.2
Upset %
-5220%
Momentum Score
Seattle Seahawks Edges
Home field advantage
Stronger pass defense (allows 20.7 vs 29.3)
Better win percentage (67% vs 17%)
San Francisco 49ers Edges
Motivated road performance
Proven consistency in tough environments
Our model favors Seattle Seahawks by 6 points — look for value on the home side covering.
Head-to-Head History
No recent matchup data available.
Injury Report
Latest injury designations from ESPN
No significant injuries reported
Team & Player Breakdown
San Francisco 49ers
Head Coach
Kyle Shanahan
Starting QB
Brock Purdy
wide-zone running scheme with layered play-action and creative receiver usage
versatile, multiple-front defense that shifts personnel based on the opponent
Seattle Seahawks
Head Coach
Mike Macdonald
Starting QB
Geno Smith
balanced, quick-rhythm attack that leverages Smith's accuracy and a deep receiving corps
aggressive, Legion-of-Boom-inspired press-coverage scheme
Key Players
Purdy's processing speed and accuracy within Shanahan's system make him one of the most efficient quarterbacks in football. His ability to identify and attack soft spots in coverage quickly is a genuine skill.
Smith's accuracy and football IQ have made him a reliable starter. His ability to operate efficiently in the short-to-intermediate area gives Seattle a consistent offensive floor.
McCaffrey's versatility as both a runner and receiver out of the backfield creates matchup nightmares for linebackers and safeties. He is the offense's most important player and the focal point of every defensive game plan.
Metcalf's combination of size and speed makes him one of the NFC's most physically imposing wide receivers. His deep-ball threat forces safeties to play back.
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San Francisco 49ers vs Seattle Seahawks — Frequently Asked Questions
Who is predicted to win the San Francisco 49ers vs Seattle Seahawks Week 12 game?+
Our AI prediction model picks the Seattle Seahawks to win the San Francisco 49ers vs Seattle Seahawks Week 12 2026 matchup with 53% confidence. The model gives the Seattle Seahawks a 53% win probability and the San Francisco 49ers a 47% win probability.
When and where is the San Francisco 49ers vs Seattle Seahawks game?+
The San Francisco 49ers face the Seattle Seahawks on Wednesday, November 25, 2026 at 4:00 PM UTC, hosted at Lumen Field. The game airs on FOX.
What is the confidence level on this NFL Week 12 prediction?+
Our machine-learning model rates this pick at 53% confidence, based on 4+ seasons of team performance data, offensive/defensive splits, recent form, home/road splits, and pace-adjusted efficiency. Higher confidence generally means the model sees a wider gap between the two teams.
What TV network is broadcasting the San Francisco 49ers at Seattle Seahawks game?+
The San Francisco 49ers at Seattle Seahawks Week 12 game is scheduled to air on FOX. Check your local listings or the NFL Predictions Hub schedule closer to kickoff for the latest broadcast information.
How accurate are NFL Predictions Hub's AI picks?+
Our XGBoost-based prediction model is trained on 4+ seasons of NFL play-by-play, team, and situational data. It tracks a rolling win rate against the moneyline that is published on our model transparency page. Individual picks are probabilistic — even a 75% confidence pick will miss 1 in 4 times over a long enough sample.
Game Information
Kickoff
Wed, Nov 25, 4:00 PM UTC
Network
FOX
Venue
Lumen Field