Arizona Cardinals @ Seattle Seahawks
Seattle Seahawks projected to win thanks to stronger defensive efficiency over Arizona Cardinals. Model assigns a 68% confidence to this outcome.
Win Probability
Team Profile
ARI
SEAKey Factors
Game Projections
Derived from each team's last 6-game scoring averages vs opponent defense
ARI
23.3
proj pts
Total O/U
46
pts
SEA
22.7
proj pts
Scoring Edges
Seattle Seahawks Offense
21.5 PPG vs Arizona Cardinals (allows 23.8)
Arizona Cardinals Offense
26.0 PPG vs Seattle Seahawks (allows 20.7)
Projections use rolling 6-game team averages. Not financial advice.
Analytics Breakdown
Model-derived betting metrics & edge factors
Proj Spread
Seahawks -1.4
Total O/U
49.9
Upset %
-6720%
Momentum Score
Seattle Seahawks Edges
Home field advantage
Stronger pass defense (allows 20.7 vs 23.8)
Better win percentage (67% vs 33%)
Arizona Cardinals Edges
Dynamic scoring attack (+4.5 PPG edge)
Motivated road performance
Proven consistency in tough environments
This matchup projects as a near pick'em — expect a tight game decided in the fourth quarter.
Head-to-Head History
No recent matchup data available.
Injury Report
Latest injury designations from ESPN
No significant injuries reported
Team & Player Breakdown
Arizona Cardinals
Head Coach
Jonathan Gannon
Starting QB
Kyler Murray
fast-paced, spread-option attack built around Murray's dual-threat ability
zone-heavy coverage scheme designed to limit explosive plays
Seattle Seahawks
Head Coach
Mike Macdonald
Starting QB
Geno Smith
balanced, quick-rhythm attack that leverages Smith's accuracy and a deep receiving corps
aggressive, Legion-of-Boom-inspired press-coverage scheme
Key Players
Murray's speed and agility make him one of the most dangerous quarterbacks in space. When healthy, his ability to extend plays and create out of structure gives Arizona an explosive element.
Smith's accuracy and football IQ have made him a reliable starter. His ability to operate efficiently in the short-to-intermediate area gives Seattle a consistent offensive floor.
Harrison Jr. brings elite physical tools to Arizona's passing game. His combination of size, speed, and polished route running makes him a legitimate star.
Metcalf's combination of size and speed makes him one of the NFC's most physically imposing wide receivers. His deep-ball threat forces safeties to play back.
Related Predictions
All picks
Arizona Cardinals vs Seattle Seahawks — Frequently Asked Questions
Who is predicted to win the Arizona Cardinals vs Seattle Seahawks Week 10 game?+
Our AI prediction model picks the Seattle Seahawks to win the Arizona Cardinals vs Seattle Seahawks Week 10 2026 matchup with 68% confidence. The model gives the Seattle Seahawks a 68% win probability and the Arizona Cardinals a 32% win probability.
When and where is the Arizona Cardinals vs Seattle Seahawks game?+
The Arizona Cardinals face the Seattle Seahawks on Sunday, November 8, 2026 at 4:00 PM UTC, hosted at Lumen Field. The game airs on FOX.
What is the confidence level on this NFL Week 10 prediction?+
Our machine-learning model rates this pick at 68% confidence, based on 4+ seasons of team performance data, offensive/defensive splits, recent form, home/road splits, and pace-adjusted efficiency. Higher confidence generally means the model sees a wider gap between the two teams.
What TV network is broadcasting the Arizona Cardinals at Seattle Seahawks game?+
The Arizona Cardinals at Seattle Seahawks Week 10 game is scheduled to air on FOX. Check your local listings or the NFL Predictions Hub schedule closer to kickoff for the latest broadcast information.
How accurate are NFL Predictions Hub's AI picks?+
Our XGBoost-based prediction model is trained on 4+ seasons of NFL play-by-play, team, and situational data. It tracks a rolling win rate against the moneyline that is published on our model transparency page. Individual picks are probabilistic — even a 75% confidence pick will miss 1 in 4 times over a long enough sample.
Game Information
Kickoff
Sun, Nov 8, 4:00 PM UTC
Network
FOX
Venue
Lumen Field