NFL Week 1 2026 Complete Game-by-Game Preview: All 16 Picks

NFL Week 1 2026 — Full Game-by-Game Preview

The 2026 NFL season is officially underway. Here is our complete game-by-game preview for all 16 Week 1 matchups, including spread picks, over/under leans, and final score projections. All lines current as of Tuesday of game week.

Thursday Night Football

Detroit Lions (-2.5) at Green Bay Packers | O/U 48.5

The Lions and Packers renew their rivalry on TNF with Detroit favored for the first time in years. Our pick: Lions -2.5, UNDER 48.5. Projected final: Lions 27, Packers 21.

Sunday Games — Early Window (1:00 PM ET)

Miami Dolphins at Buffalo Bills (-6) | O/U 51.5

Josh Allen at home against a division rival in the opener. Our pick: Bills -6, OVER 51.5. Projected final: Bills 34, Dolphins 28.

Cincinnati Bengals at Pittsburgh Steelers | Bengals -1.5 | O/U 44.5

The North Division opener between bitter rivals. Our pick: Bengals -1.5, UNDER 44.5. Projected final: Bengals 23, Steelers 17.

Houston Texans (-3) at Indianapolis Colts | O/U 46.5

The South Division rivalry with Stroud leading Houston on the road. Our pick: Texans -3, UNDER 46.5. Projected final: Texans 24, Colts 20.

New York Jets at New England Patriots | Jets -3.5 | O/U 42.5

The AFC East rivalry with Drake Maye's debut in New England. Our pick: Patriots +3.5, UNDER 42.5. Projected final: Jets 23, Patriots 18.

Minnesota Vikings at Chicago Bears | Vikings -2.5 | O/U 46.5

Caleb Williams faces a veteran Vikings defense in Chicago. Our pick: Vikings -2.5, UNDER 46.5. Projected final: Vikings 24, Bears 17.

New Orleans Saints at Atlanta Falcons | Falcons -1.5 | O/U 45.5

The NFC South rivalry opener in Atlanta. Our pick: Saints +1.5, UNDER 45.5. Projected final: Falcons 22, Saints 20.

Washington Commanders at New York Giants | Commanders -2 | O/U 41.5

Jayden Daniels leads Washington into the Meadowlands. Our pick: Commanders -2, UNDER 41.5. Projected final: Commanders 21, Giants 16.

Jacksonville Jaguars at Tennessee Titans | Jaguars -3 | O/U 43.5

The South Division battle with Trevor Lawrence favored on the road. Our pick: Titans +3, UNDER 43.5. Projected final: Jaguars 23, Titans 20.

Tampa Bay Buccaneers (-6.5) at Carolina Panthers | O/U 44.5

Baker Mayfield and the Bucs face a rebuilding Panthers squad. Our pick: Buccaneers -6.5, UNDER 44.5. Projected final: Buccaneers 28, Panthers 17.

Sunday Games — Late Window (4:00–4:25 PM ET)

Baltimore Ravens (-7) at Las Vegas Raiders | O/U 43.5

Lamar Jackson dominates a rebuilding Raiders team on the road. Our pick: Ravens -7, UNDER 43.5. Projected final: Ravens 31, Raiders 17.

Los Angeles Chargers (-2.5) at Denver Broncos | O/U 44.5

Jim Harbaugh's second year leads the Chargers into Denver. Our pick: Chargers -2.5, OVER 44.5. Projected final: Chargers 27, Broncos 21.

Kansas City Chiefs (-3) vs Baltimore Ravens | O/U 49.5

The AFC Championship rematch in Kansas City. Our pick: Chiefs -3, UNDER 49.5. Projected final: Chiefs 24, Ravens 20.

Los Angeles Rams (-4) at Arizona Cardinals | O/U 47.5

McVay's Rams travel to Glendale for the West Division opener. Our pick: Cardinals +4, UNDER 47.5. Projected final: Rams 27, Cardinals 24.

Seattle Seahawks at San Francisco 49ers (-5.5) | O/U 45.5

The 49ers host their division rival in the West opener. Our pick: 49ers -5.5, UNDER 45.5. Projected final: 49ers 26, Seahawks 17.

Sunday Night Football

Dallas Cowboys at Philadelphia Eagles (-4.5) | O/U 47.5

The NFC East rivalry in primetime to close out Sunday. Our pick: Eagles -4.5, OVER 47.5. Projected final: Eagles 30, Cowboys 24.

Monday Night Football

Baltimore Ravens (-7) at Las Vegas Raiders | O/U 43.5

Lamar Jackson leads Baltimore in the Monday night finale. Our pick: Ravens -7, UNDER 43.5. Projected final: Ravens 34, Raiders 16.

Week 1 2026 Record Projection

Our staff's combined Week 1 ATS record target is 10-6, consistent with the market accuracy floor in a high-information week. We are most confident in our divisional game unders and the top-tier home favorites covering in their season openers. Good luck with your Week 1 2026 NFL picks.